New improvements in oligonucleotide synthesis by use of the p-nitrophenylethyl phosphate blocking group and its deprotection by DBU or DBN

DOI: 10.1016/S0040-4039(00)71364-5

Source and publish data:

Tetrahedron Letters p. 1181 - 1184 (1980)

Update date:2022-08-04

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Authors:

Uhlmann, Eugen

Pfleiderer, Wolfgang

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Article abstract of DOI:10.1016/S0040-4039(00)71364-5

Phosphate protection in the phosphotriester approach is improved by the new, versatile p-nitrophenylethyl group due to its stability in the condensation step and its clean removal by DBU and DBN respectively.

Full text of DOI:10.1016/S0040-4039(00)71364-5

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