Chemical and Pharmaceutical Bulletin p. 1774 - 1779 (1993)
Update date:2022-08-02
Topics:
Umehara
Sugawa
Kuroyanagi
Ueno
Taki
In the course of studying differentiation-inducers from plants, their isolation was performed from the methanolic extract of Arctium Fructus (the fruits of Arctium lappa L., Compositae), and then their phagocytic activity on differentiated mouse myeloid leukemia cells (MI) was monitored. Thirteen compounds, including five new ones, were isolated as differentiation-inducers toward MI cells. These consisted of two lignans, eight sesquilignans and three dilignans. Arctigenin (2) was the most effective compound of all those isolated, and it induced differentiation of MI cells at a concentration 0.5 μM. Sesquilignans were less effective than lignans and dilignans showed even weaker activity. These lignoids were inactive towards a human acute promyelocytic leukemia cell line (HL-60).
View MoreJi'an Hairui Natural Plant Co. Ltd.
Contact:0796-8105528
Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Contact:+86-25-85281586
Address:13F,Bld2#,South of Longpan Road
Taixing Shenfeng Chemical Co., Ltd.
Contact:+86-523-87117033, 87117666
Address:4# Yinsanlu, Huangqiao town, Taixing, Jiangsu, China.
Luoyang Aoda chemical Co.,Ltd.
Contact:+86-379-67518785 67516588
Address:MiaoWan industry district,YanShi City,Henan,China
Contact:+86-570-4336358
Address:No.87 Building,Tianqian,Sidu Town
Doi:10.1023/B:RUCB.0000011871.28637.78
(2003)Doi:10.1023/B:PHAM.0000029281.12753.25
(2004)Doi:10.1021/ol049049q
(2004)Doi:10.1039/c39800000297
(1980)Doi:10.1021/ja00541a025
(1980)Doi:10.1021/jacs.9b12782
(2020)
