Journal of Organic Chemistry p. 157 - 164 (1981)
Update date:2022-08-02
Topics:
Hasan, Iltifat
Marinelli, Edmund R.
Lin, Li-Ching Chang
Fowler, Frank W.
Levy, Alan B.
N-(tert-Butoxycarbonyl)pyrrole and N-(tert-butoxycarbonyl)indole have been prepared and lithiated at the 2-position with lithium 2,2,6,6-tetramethylpiperidide and tert-butyllithium, respectively.These lithium reagents react with a variety of electrophiles to give the 2-substituted N-(tert-butoxycarbonyl)pyrroles and N-(tert-butoxycarbonyl)indoles.The N-(tert-butoxycarbonyl) substituent may be removed rapidly and in high yield from the pyrrole derivatives under basic conditions.For the indole derivatives, the protecting group may be removed with either acidic or basic conditions.
View MoreContact:+86-913-2223392
Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China
Shanghai Sungo Technology Chemical Co., Ltd
Contact:0086-21-51385579
Address:Room2010, F/20, Tonghua Plaza, NO 345 Jinxiang Road, Jinqiao Export Processing Zone, Shanghai, 201206 P.R.CHINA
website:http://www.lidepharma.com
Contact:+86-25-58409506
Address:N0.2-309 2/F Chungking Express Nos.36 Nathan Road，Kowloon, HK
Dezhou Longteng Chemical Co., Ltd.
website:http://www.sodium-methoxide.cn/
Contact:0086-18866052283
Address:Xinhua Industrial Zone, Dezhou City, Shandong Province, China
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Doi:10.3762/BJOC.16.208
(2020)Doi:10.1016/j.ejmech.2014.04.009
(2014)Doi:10.1021/acs.orglett.5b01860
(2015)Doi:10.1021/om200607h
(2011)Doi:10.1021/jm500073h
(2014)Doi:10.1080/10426507.2011.553501
(2011)
