REACTION OF CARBOXYLATE SALTS WITH CYCLIC PHOSPHORAMIDATES : AMIDE BOND FORMATION BY PRIOR AMINE CAPTURE

Article abstract of DOI:10.1016/S0040-4039(00)78585-6

Tri- or tetraalkyl-ammonium carboxylates react with 2-alkylamino-2-oxo-1,3,2-benzodioxaphospholes at 25 deg C to give amides or peptides, probably by a nucleophilic attack on phosphorous followed by a cascade of intramolecular acyl transfer reaction.