Steroids p. 611 - 619 (1980)
Update date:2022-09-26
Topics:
Evrain Ch.
Rajkowski
Cittanova
Jayle
Three fluorescence-labelled derivatives of testosterone were prepared consisting of the steroid separated from the fluorochrome by a hydrocarbon 'bridge'. 'Bridges' of different lengths (C2 to C7) were used as the length required to avoid steric hindrance effects by the fluorochrome in studies on steroid-protein binding was unknown. The three derivatives prepared were: 17β-hydroxy-4-androsten-3-one 3-(O-(N-(2'-mercapto)ethyl)carbamoylmethyl)oxime, 17β-hydroxy-4-androsten-3-one 3-(o-(N-(3'-amino)propyl)carbamoylmethyl)oxime and 17β-hydroxy-4-androsten-3-one 3-(O-(N-(7'-amino)heptyl)carbamoylmethyl)oxime. These were then coupled with either a dansyl or a fluorescein molecule. Overall yields were sufficient and the products immunoreactive with anti-testosterone antiserum.
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Doi:10.1039/c39800000742
(1980)Doi:10.1002/mrc.2316
(2008)Doi:10.1007/BF00513843
(1984)Doi:10.1016/S0040-4039(00)77395-3
(1980)Doi:10.1016/S0040-4020(99)00746-2
(1999)Doi:10.1039/b404937c
(2004)