Tetrahedron p. 5633 - 5636 (1985)
Update date:2022-08-04
Topics:
Thorsen, M.
Andersen, T. P.
Pedersen, U.
Yde, B.
Lawesson, S.-O.
Hansen. H. F.
The easily available 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's Reagent), 1, has been tested as a coupling reagent for racemization in peptide synthesis.The assay procedure is separation of stereomeric products by HPLC.Z-S-Pro-S-Val-S-Pro-OtBu and Z-S-Leu-S-Phe-S-Val-OtBu have been used as test peptides in 2+1 segment couplings, and only a small amount of epimerization (0.5 and <0.1percent, respectively) has been observed.
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