A practical, general three-component coupling approach to prostaglandin and non-prostaglandin-related skeleta

Article abstract of DOI:10.1021/ja00105a010

Starting with a terminal alkyne, a one-pot, six-step sequence has been developed which results in prostaglandin and related skeleta in high yields. The method involves a transmetalation between organozirconium and cuprate species, as well as another betwe