Design and Synthesis of Highly Active Peroxisome Proliferator-Activated Receptor (PPAR) β/δ Inverse Agonists with Prolonged Cellular Activity

DOI: 10.1002/cmdc.201500594

Source and publish data:

ChemMedChem p. 488 - 496 (2016)

Update date:2022-08-02

Topics:

Authors:

Toth, Philipp M.

Lieber, Sonja

Scheer, Frithjof M.

Schumann, Tim

Schober, Yvonne

Nockher, Wolfgang A.

Adhikary, Till

Müller-Brüsselbach, Sabine

Müller, Rolf

Diederich, Wibke E.

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Article abstract of DOI:10.1002/cmdc.201500594

Based on 3-(((4-(hexylamino)-2-methoxyphenyl)amino)sulfonyl)-2-thiophenecarboxylic acid methyl ester (ST247, compound 2), a recently described peroxisome proliferator-activated receptor (PPAR)β/δ-selective inverse agonist, we designed and synthesized a se

Full text of DOI:10.1002/cmdc.201500594

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