Four N-benzyl-substituted 2-ethyl-3-hydroxypyridin-4-ones

Article abstract of DOI:10.1107/S0108270198008488

The molecular structures of 1-benzyl-2-ethyl-3-hydroxypyridin-4-one hydrate [(1), C₁₄H₁₅NO₂.H₂O], 2-ethyl-3-hydroxy-1-(4-methylbenzyl)pyridin-4-one [(2), C₁₅H₁₇-NO₂], 2-ethyl-1-(4-fluorobenzyl)-3-hydroxypyridin-4-one [(3), C₁₄H₁₄FNO₂] and 2-ethyl-3-hydroxy-1-(4-trifluoromethylbenzyl)pyridin-4-one hemihydrate [(4), C₁₅H₁₄-F₃NO₂.0.5H₂O] have been determined. The compounds all exhibit mutually hydrogen-bonded dimeric pairs. In the case of (1) and (2), the molecules of the dimer are symmetry related, while in (3) and (4), two independent molecules of the asymmetric unit are linked. For the hydrates (1) and (4), the dimeric pairs are linked by further hydrogen bonds through the water molecules.