Tetrahedron Letters p. 2077 - 2080 (1980)
Update date:2022-08-02
Topics:
Ojima, Iwao
Inaba, Shin-ichi
Asymmetric synthesis of β-lactams by means of the reaction of dimethyl-ketene silyl acetal with (S)-alkylidene(1-arylethyl)amines in the presence of titanium tetrachloride was studied.The extent of the asymmetric induction was in the range of 44-78percent (diastereomeric purity 72-89percent) and the (S)-configuration was turned to be preferentially induced at the 4C position of the resulting β-lactams.
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