Synthesis of α-Phenyl Proline Derivatives via 1,3-Dipolar Cycloaddition of Chiral Stabilised Azomethine Ylids.

DOI: 10.1016/0957-4166(95)00321-F

Source and publish data:

Tetrahedron Asymmetry p. 2465 - 2468 (1995)

Update date:2022-09-26

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Authors:

Anslow, Amberley. S.

Harwood, Laurence. M.

Lilley, Ian. A.

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Article abstract of DOI:10.1016/0957-4166(95)00321-F

The preparation of (3S,5R)-3,5-diphenylmorpholinone 1 and subsequent diastereoselective 1,3-dipolar cycloaddition of its formaldehyde derived azomethine ylid is described.Removal of the chiral template furnishes α-phenyl proline derivatives.

Full text of DOI:10.1016/0957-4166(95)00321-F

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