Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites

DOI: 10.1016/S0960-894X(98)00131-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 913 - 918 (1998)

Update date:2022-08-05

Topics:

Authors:

Eda, Masahiro

Ashimori, Atsuyuki

Akahoshi, Fumihiko

Yoshimura, Takuya

Inoue, Yoshihisa

Fukaya, Chikara

Nakajima, Masahide

Fukuyama, Hajime

Imada, Teruaki

Nakamura, Norifumi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00131-0

Peptidyl difluoromethylene ketone derivatives were designed to take advantage of probable additional interactions with the S' subsite of human heart chymase. They showed potent inhibitory activities against human heart chymase and were more efficient than bovine chymotrypsin.

Full text of DOI:10.1016/S0960-894X(98)00131-0

Products guided by the article

Product name:(3S,4R)-4-Amino-2,2-difluoro-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

Cas No:764628-83-3

R&D Labs maybe for 764628-83-3

Tianjin Te-An Chemtech Co., Ltd.(expird)

Contact:+86-22-65378638

Address:A5-8, No.80 Haiyun Street, TEDA
Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
QUZHOU ZIO I/E CO.;LTD

Contact:13357117572

Address:No.149 Shiji dadao Road.
Shanghai Kangxin Chemical Co., Ltd

Contact:+86 21 60717227

Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai
Changzhou naidechemical Co.Ltd

Contact:+86-519-82589807

Address:NO.25,Houyang street,Jintan,Changzhou City

Relevant to this article

Synthesis of all-E- and 9Z-heteroaryl-retinoic acid applying palladium catalyzed coupling reaction of (arylvinyl)tributyl stannane with vinyl triflate

Doi:10.1055/s-2001-18104
(2001)
Synthesis and structural studies of phosphorus carbonyl manganacycles containing the tetraphenyldiselenoimidodiphosphinato ligand

Doi:10.1016/j.jorganchem.2006.03.027
(2006)
Potential anticonvulsants. 1. 5-Benzylhydantoins.

Doi:10.1021/jm00136a018
(1981)
Unusual coordination mode of tetradentate Schiff base cobalt(iii) complexes

Doi:10.1039/c2dt11871h
(2012)
Polymer-Supported Phase-Transfer Catalysts. Crown Ethers and Cryptands Bonded by a Long Alkyl Chain to a Polystyrene Matrix

Doi:10.1021/jo00323a029
(1981)
Asymmetric total synthesis of gracilamine and determination of its absolute configuration

Doi:10.1021/acs.orglett.7b02517
(2017)

Article Doi