Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites

DOI: 10.1016/S0960-894X(98)00131-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 913 - 918 (1998)

Update date:2022-08-05

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Authors:

Eda, Masahiro

Ashimori, Atsuyuki

Akahoshi, Fumihiko

Yoshimura, Takuya

Inoue, Yoshihisa

Fukaya, Chikara

Nakajima, Masahide

Fukuyama, Hajime

Imada, Teruaki

Nakamura, Norifumi

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Article abstract of DOI:10.1016/S0960-894X(98)00131-0

Peptidyl difluoromethylene ketone derivatives were designed to take advantage of probable additional interactions with the S' subsite of human heart chymase. They showed potent inhibitory activities against human heart chymase and were more efficient than bovine chymotrypsin.

Full text of DOI:10.1016/S0960-894X(98)00131-0

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