A Novel, Simple and Cheap Source of Alkyl Radicals from Alcohols, Useful for Heterocyclic Substitution

DOI: 10.1246/cl.1992.1295

Source and publish data:

Chemistry Letters p. 1295 - 1298 (1992)

Update date:2022-08-05

Topics:

Authors:

Coppa, Fausta

Fontana, Francesca

Lazzarini, Edoardo

Minisci, Francesco

Pianese, Giuseppe

Zhao, Lihua

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Article abstract of DOI:10.1246/cl.1992.1295

Alkyl radicals were easily produced from secondary or tertiary alcohols in a cheap and simple way by silver-catalyzed decarboxylation of oxalic acid monoesters by S2O8(2-).They were utilized for the alkylation of heteroaromatic bases in a two-phase system, with high yields and selectivity.

Full text of DOI:10.1246/cl.1992.1295

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