RSC Advances p. 25681 - 25685 (2013)
Update date:2022-09-26
Topics:
Zolfigol, Mohammad Ali
Tavasoli, Mahsa
Moosavi-Zare, Ahmad Reza
Moosavi, Parvin
Kruger, Hendrik Gerhardus
Shiri, Morteza
Khakyzadeh, Vahid
In this study, a green, simple and efficient method for the preparation of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c] pyrazoles by means of a one-pot four component condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate is reported. The reaction utilizes isonicotinic acid as a dual and biological organocatalyst at 85 °C under solvent-free conditions.
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Doi:10.1016/0040-4020(80)80145-1
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