Two New Thia Chalcones

Article abstract of DOI:10.1021/je00024a043

4-Hydroxy-3-nitro- and 2-hydroxy-5-nitroacetophenone (1 and 3), both obtained by nitrating the parent hydroxy ketone, were condensed with thiophene-α-carboxaldehyde in the presence of dilute NaOH to give the appropriate yellow thia chalcones 2, mp 147 deg C, and 4, mp 190 -191 deg C, with yields of 72.5 percent and 71 percent, respectively.The chalcones (C13H9NSO4) were characterized by elemental analysis as well as by their IR and (1)H NMR spectra.