127. Conformationally Controlled Odor Perception in 'Steroid-type' Scent Molecules

Article abstract of DOI:10.1002/hlca.19830660503

A series of compounds possessing a 'steroid-type' scent and related to 4-(4'-t-butylcyclohexyl)-4-methyl-2-pentanones (1 and 2) have been synthesized.The odor of these compounds has been found to be dependent on their conformation; only when the molecule can assume a steroid-like shape there is an interaction with the odor chemoreceptor.