Journal of the Chemical Society. Chemical communications p. 1224 - 1226 (1980)
Update date:2022-08-04
Topics: Synthesis Acylation Regioselectivity Heterocyclic compounds Deprotonation Organic synthesis Coumarin Carboxylic Acids Benzofuran Chromone VINYL CARBANIONS Flavone Anionic Intermediate Synthetic Methodology
Costa, Ana M. B. S. R. C. S.
Dean, Francis M.
Jones, Michael A.
Smith, Dennis A.
Varma, Rajender S.
Lithium di-isopropylamide at -70 deg C can remove the α-proton from benzofuran in the absence of activating groups and the β-proton if such groups are present; in flavone and 4-methoxycoumarin β-deprotonation occurs readily and the carbanions are easily carboxylated giving acids not previously accessible, while in 2,6-dimethylchromone β-deprotonation is kinetically favoured allowing 3-acylation to be achieved separately from the conventional acylation at the 2-methyl group.
View MoreSHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD
Contact:86-21-60560171
Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
JIANGXI AIFEIMU TECHNOLOGY CO.，LTD
Contact:+86-570-6040289
Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
JiangXi Keyuan Biopharma Co., LTD.
Contact:+86-563-6833666
Address:Guangde Fine Chemical Zone, Anhui Province, China
Contact:+44 (0)2036089360-31
Address:Chanceryhouse,Chancery Lan
Doi:10.1016/j.jssc.2008.02.021
(2008)Doi:10.1039/c39800001182
(1980)Doi:10.1021/ja992059f
(2000)Doi:10.1021/jo01106a624
(1958)Doi:10.1016/0040-4020(80)80151-7
(1980)Doi:10.1002/chem.200400144
(2004)
