CLAISEN ORTHO ESTER REARRANGEMENT WITH TRIMETHYL β-(METHOXY)ORTOPROPIONATE: A TERMALLY STABLE SYNTHON FOR THE PREPARATION OF METHYL α-SUBSTITUTED ACRYLATES

Article abstract of DOI:10.1016/S0040-4039(00)77851-8

Trimethyl β-(methoxy)ortopropionate, a compound which is thermally stable at 190 deg C for proplonged times, may be utilized as a synthon for the preparation of methyl α-substituted acrylates via Claisen ortho ester rearrangement with allylic alcohols followed by β-elimination of methanol with base.