SYNTHESIS OF 2-AMINO-3,8-DIMETHYLIMIDAZOQUINOXALINE (Me-IQx), A POTENT MUTAGEN ISOLATED FROM FRIED BEEF

DOI: 10.1246/cl.1981.675

Source and publish data:

Chemistry Letters p. 675 - 678 (1981)

Update date:2022-07-30

Topics:

Authors:

Kasai, Hiroshi

Shiomi, Tomoko

Sugimura, Takashi

Nishimura, Susumi

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Article abstract of DOI:10.1246/cl.1981.675

A potent mutagen, 2-amino-3,8-dimethylimidazo<4,5-f>quinoxaline (Me-IQx), isolated from fried beef and its 3,7-dimethyl derivative were synthesized from 6-amino-3-methylquinoxaline and 6-amino-2-methylquinoxaline, respectively.These compounds showed strong mutagenic activity towards Salmonella typhimurium TA98 in the presence of S9 Mix.

Full text of DOI:10.1246/cl.1981.675

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