Isolation and identification of impurities in 4-acetyl-2-(2'-hydroxyethyl)-5,6-bis (4-chlorophenyl)- 2H-pyridazin-3-one, an antihypertensive agent

Article abstract of DOI:10.1002/jps.2600700419

Three trace impurities found in 4-acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one (II), a novel antihypertensive agent, were isolated by a combination of low-pressure liquid chromatography and preparative TLC. These impurities were i