Journal of Organic Chemistry p. 4980 - 4987 (1981)
Update date:2022-08-04
Topics:
Tsuda, Tetsuo
Chujo, Yoshiki
Takahashi, Seiji
Saegusa, Takeo
Copper(I,II) β-keto carboxylates undergo a specific two-step decarboxylation.For example, the decarboxylation of copper(I) 1-oxocyclohexane-2-carboxylate (1) evolves CO2 in a 50percent yield in dimethylformamide (DMF) at 70 deg C.No further CO2 evolution beyond this 50percent decarboxylation occurs at 70 deg C.At a higher temperature of 120 deg C., the remaining 50percent of the CO2 is released.This specific two-step decarboxylation of 1 results from the intermediate formation of a dicopper(I) salt of the enol of 1-oxocyclohexane-2-carboxylic acid (10) which is stable to decarboxylation at 70 deg C.Compound 10 is isolated from the reaction mixture after the 50percent decarboxylation.Decarboxylations of copper(I,II) benzoylacetates, copper(I) oxaloacetate, copper(II) 1-oxo-cyclohexane-2-carboxylate, and copper(II) chloride 1-oxocyclohexane-2-carboxylate also proceed stepwise in DMF.On the other hand, copper(I,II) benzoylcyclopropane-1-carboxylates without an enolizable α-hydrogen atom evolve CO2 in a usual one-step manner.The present specific two-step decarboxylation of copper(I,II) β-keto carboxylates provides a novel type of regulation of the decarboxylation of β-keto acids and also a method of generating copper(I,II) enolate.The bearing of the two-step decarboxylation of copper(I) β-keto carboxylates on both the Cu(I)-mediated carboxylation of ketones and organic synthesis is also described.
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Doi:10.1016/S0040-4039(01)81779-2
(1981)Doi:10.1021/jo048924i
(2004)Doi:10.1016/S0022-328X(00)82965-4
(1981)Doi:10.1039/P19810002363
(1981)Doi:10.1016/S0957-4166(00)86144-3
(1991)Doi:10.1021/ja00408a073
(1981)