Long-Bridged Cyclonucleosides. 1. Synthesis and Reactions of Some Purine 8,2'-(Nα-Methylhydrazino) and 8,2'-(Nα-Methyloxamido) Cyclonucleosides

Article abstract of DOI:10.1021/jo00338a023

For expansion of the range of the model conformations of cyclonucleosides, synthesis of some long-bridged purine cyclonucleosides has been achieved.Thus, 8-bromo-2'-O-tosyladenosine (1a) and its guanine analogue (1b) with methylhydrazine gave the correspo