Journal of Medicinal Chemistry p. 1329 - 1332 (1981)
Update date:2022-08-05
Topics:
Witiak, Donald T.
Trivedi, Bharat K.
Campolito, Laura B.
Zwilling, Bruce S.
Reiches, Nancy A.
The synthesis for trans and cis tricyclic bis(dioxopiperazine)s 5 and 6 from pyrazine-2,3-dicarboxamide (7) is described.Stereoselective antimetastatic activity differences for these analogues were observed following pretreatment of B16-F10 melanoma cells in vitro.Activities for these isomers were compared with selected intermediates, and the data are discussed in relation to previous results obtained with cis- and trans-cyclopropane analogues.
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