Synthesis of Pseudo Cofactor Analogues as Potential Inhibitors of the Folate Enzymes

Article abstract of DOI:10.1021/jm00344a014

Reaction of 5,6,7,8-tetrahydrofolic acid (THF, 7) with phosgene, thiophosgene, and cyanogen bromide gave the bridged derivatives, 5,10-(CO)-THF (8), 5,10-(CS)-THF (9), and 5,10-(C=NH)-THF (11), respectively.Catalytic hydrogenation of 10-(chloroacetyl)foli