SYNTHESIS OF 3-HALOISOXAZOLES BY NOVEL OXIDATIVE DEGRADATION OF THE SIDE-CHAIN OF 3-(3-HALO-ISOXAZOL-5-YL) PROPIONIC ACIDS

Article abstract of DOI:10.1016/S0040-4020(01)98922-7

A novel method for the oxidative degradation of the side-chain of 3-(3-haloisoxazol-5-yl) propionic acids has been developed.The E-3-(3-chloroisoxazol-5-yl) propenoic acid 13a obtained by treatment of the s-triazolo<2,3-c> quinazolin-4-ium iodide 11a with PhI(OAc)2 and Bz2O2, respectively, and subsequent hydroxysis, has been used for the synthesis of numerous 3-haloisoxazole derivatives.