Journal of the Chemical Society. Perkin transactions I p. 2912 - 2919 (1981)
Update date:2022-08-02
Topics: Yield NMR spectroscopy reflux Chromatography Stirring TLC (thin-layer chromatography) Workup Reaction Setup Quenching Extraction Reduction Reaction Selective Reduction Lactams Magnesium (Mg) Carbonyl Group (C=O) Double Bond (C=C)
Brettle, Roger
Shibib, Sa'ad M.
αβ-Olefinic amides with various substitution patterns at the carbon-carbon double bond and at nitrogen are all reduced to the corresponding saturated amides by magnesium and methanol.The same reducing system reduces N-benzyl-8-azabicyclo<4.3.0>nona-1(6),3-dien-7-ones at the conjugated double bond to give mixtures of the cis- and trans-dihydro-derivatives; the isolated, non-conjugated double bond is not reduced, even in the 3,4-diphenylsubstituted compound.Magnesium and methanol reduces quinolin-2(1H)-ones to their 3,4-dihydro-derivatives, and 5,6,7,8-tetrahydroquinolin-2(1H)-one to a mixture of two dihydro-derivatives.
View MoreChangzhou Ansciep Chemical Co.,Ltd.
Contact:+86 519 8630 5871
Address:A-710 Boan International, 8 East Guangdian Road,Wujin,Changzhou
NINGBO YINLIANG FOREIGN TRADE CO., LTD.
Contact:+86-574-87834016 / 87898057
Address:23F NO.666JINYU ROAD,YINGZHOU DISTRICT,NINGBO.CHINA
Zhangjiagang Jianing Import & Export Co.,Ltd.
Contact:086-512-55379012 13913607595
Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
Zhejiang Newfine Industry Co.,Ltd.
Contact:+86-573-82262042
Address:No.225,Dongqing Road, garoms@163.com
Shanghai HengXun Pharmaceutical Tech. Co., Ltd.
Contact:86-86-52730756
Address:Room 603, No. 240, Tianmuzhong Road, Zhabei, Shanghai, China
Doi:10.1246/cl.1982.71
(1982)Doi:10.1021/ja01252a042
(1943)Doi:10.1016/S0040-4020(01)92377-4
(1981)Doi:10.1016/S0960-894X(01)00789-2
(2002)Doi:10.3109/00498259609046689
(1996)Doi:10.1021/ol9908979
(1999)
