ENANTIOSELECTIVE SYNTHESIS OF C3-C10 FRAGMENT (NORTHEASTERN ZONE) OF MAYTANSINOIDS WITH 4-CHIRAL CENTERS (4S,5S,6R,7S)

Article abstract of DOI:10.1016/S0040-4039(01)82028-1

The major precursor to the maytansinoids containing 4 non-racemic chiral centers has been prepared in gram quantities, suitable for further synthesis.The route to (+)-1 was accomplished in 13 steps including several highly stereocontrolled reactions which