The synthesis of 1-aminobenzylphosphonic acids from benzylidenediphenylmethylamines, for use as structural units in antithrombotic tripeptides

DOI: 10.1016/S0040-4020(01)90420-X

Source and publish data:

Tetrahedron p. 5099 - 5108 (1994)

Update date:2022-08-02

Topics:

Authors:

Green, Donovan

Patel, Geeta

Elgendy, Said

Baban, Jehan A.

Claeson, Goran

Kakkar, Vijay V.

Deadman, John

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Article abstract of DOI:10.1016/S0040-4020(01)90420-X

Acid hydrolyses of O,O-dimethyl or O,O-diethyl 1-(diphenylmethylamino) benzylphosphonate intermediates 2, formed from the addition at elevated temperature of dimethyl or diethyl phosphite to benzylidenediphenylmethylamines 1, generates 1-aminobenzylphosphonic acids 3 in good yield.

Full text of DOI:10.1016/S0040-4020(01)90420-X

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