Selective para metalation of unprotected 3-methoxy and 3,5-dimethoxy benzoic acids with n-butyl lithium-potassium tert-butoxide (LIC-KOR): Synthesis of 3,5-dimethoxy-4-methyl benzoic acid

DOI: 10.1016/S0040-4039(00)00320-8

Source and publish data:

Tetrahedron Letters p. 3157 - 3160 (2000)

Update date:2022-09-26

Topics:

Authors:

Sinha, Surajit

Mandal, Bhubaneswar

Chandrasekaran, Srinivasan

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Article abstract of DOI:10.1016/S0040-4039(00)00320-8

The potassium salt of 3-methoxy and 3,5-dimethoxy benzoic acids undergoes deprotonation at the position para to the carboxylate group selectively when treated with LIC-KOR in THF at -78°C and it has been extended to the synthesis of 3,5-dimethoxy-4-methyl benzoic acid. (C) 2000 Elsevier Science Ltd.

Full text of DOI:10.1016/S0040-4039(00)00320-8

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