Steroids p. 651 - 666 (1981)
Update date:2022-08-03
Topics:
Deraedt, R.
Benzoni, J.
Fortin, M.
Philibert, D.
Replacement of the characteristic dihydroxyacetone side chain of corticoids by a 17α-alkynyl-17β-hydroxy moiety was investigated.It was found that, in particular, the 17α-propynyl substitution is favorable for high local anti-inflammatory activity with reduced systemic effects.Moreover, these compounds were found to be devoid of any affinity for the aldosterone receptor, and may thus be considered as pure glucocorticoids.
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Doi:10.1246/bcsj.58.1599
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(1946)Doi:10.1080/00397911.2013.765484
(2013)