17α-Alkynyl-11β,17-dihydroxyandrostane derivatives: A new class of potent glucocorticoids

Article abstract of DOI:10.1016/0039-128X(81)90084-2

Replacement of the characteristic dihydroxyacetone side chain of corticoids by a 17α-alkynyl-17β-hydroxy moiety was investigated.It was found that, in particular, the 17α-propynyl substitution is favorable for high local anti-inflammatory activity with reduced systemic effects.Moreover, these compounds were found to be devoid of any affinity for the aldosterone receptor, and may thus be considered as pure glucocorticoids.