Chemical and Pharmaceutical Bulletin p. 1071 - 1081 (2004)
Update date:2022-08-03
Topics:
Kamata, Junichi
Okada, Toshimi
Kotake, Yoshihiko
Niijima, Jun
Nakamura, Katsuji
Uenaka, Toshimitsu
Yamaguchi, Atsumi
Tsukahara, Kappei
Nagasu, Takeshi
Koyanagi, Nozomu
Kitoh, Kyosuke
Yoshimatsu, Kentaro
Yoshino, Hiroshi
Sugumi, Hiroyuki
As part of a series of studies to discover new topoisomerase II inhibitors, novel pyrimidoacridones, pyrimidophenoxadines, and pyrimidocarbazoles were synthesized, and in vitro and in vivo antitumor activities and DNA-protein and/or DNA-topoisomerase II c
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