Addition of Trimethylsilyl Enol Ethers to Isoquinolinium Salts: A Facile Synthesis of 1-(2-Oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)- 1,2-dihydroisoquinolines and Their Cyclization for the Synthesis of the Isoquinoline Alkaloid Skeleton

DOI: 10.1021/jo00201a013

Source and publish data:

Journal of Organic Chemistry p. 63 - 68 (1985)

Update date:2022-07-30

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Authors:

Akiba, Kin-ya

Nakatani, Masayuki

Wada, Makoto

Yamamoto, Yohsuke

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Article abstract of DOI:10.1021/jo00201a013

The addition of trimethylsilyl enol ethers to 2-acylisoquinolinium salts afforded 1-(2-oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)-1,2-dihydroisoquinolines (3) in excellent yields.These compounds were cyclized with bases to give benzoquinolizine derivative

Full text of DOI:10.1021/jo00201a013

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