SYNTHESIS OF OLIGORIBONUCLEOTIDES USING 4-METHOXYBENZYL GROUP AS A NEW PROTECTING GROUP OF THE 2'-HYDROXYL GROUP OF ADENOSINE

Article abstract of DOI:10.1246/cl.1982.189

4-Methoxybenzyl group was introduced directlyto the 2'-hydroxyl group from the reaction of adenosine with 4-methoxybenzyl bromide in the presence of sodium hydride.The 2'-O-(4-methoxybenzyl)-adenosine can be successfully used in the synthesis of oligoribo