Bioorganic and Medicinal Chemistry Letters p. 3091 - 3094 (1997)
Update date:2022-08-04
Topics:
Ducki, Sylvie
Hadfield, John A.
Hepworth, Lucy A.
Lawrence, Nicholas J.
Ching-Ying, Liu
McGown, Alan T.
A series of (E)-1-phenylbut-1-en-3-ones, based on the naturally occurring (E)-1-(4'-hydroxyphenyl)but-1-en-3-one [IC50 (K562) 60 μM], was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-1-(Pentafluorophenyl)but-1-en-3-one [IC50 (K562) 1.8 μM] was found to be over 30-fold more active than 1.
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