Journal of Medicinal Chemistry p. 1195 - 1201 (1986)
Update date:2022-08-04
Topics:
Collins, Paul W.
Gasiecki, Alan F.
Jones, Peter H.
Bauer, Raymond F.
Gullikson, Gary W.
et al.
The synthesis and gastric antisecretory activity in dogs of seven α chain diene derivatives of misoprostol are described.The key intermediates in the preparation of these compounds were C-9 tert-butyldimethylsilyl enol ethers that were obtained by in situ
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