Enzymes in Organic Synthesis. 25. Heterocyclic Ketones as Substrates of Horse Liver Alcohol Dehydrogenase. Highly Stereoselective Reductions of 2-Substituted Tetrahydropyran-4-ones

DOI: 10.1021/ja00381a025

Source and publish data:

Journal of the American Chemical Society p. 4666 - 4671 (1982)

Update date:2022-08-04

Topics: Ketones Enzymes Substrates Stereoselective Organic synthesis Heterocyclic Reductions

Authors:

Haslegrave, J. Anthony

Jones, J. Bryan

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Article abstract of DOI:10.1021/ja00381a025

Horse liver alcohol dehydrogenase (HLADH) has been found to be an efficient catalyst for the reduction of O-heterocyclic ketones.Preparative-scale HLADH-catalyzed reductions of 2-substituted tetrahydropyran-4-ones are enantioselective, with reduction of e

Full text of DOI:10.1021/ja00381a025

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