Journal of the American Chemical Society p. 4666 - 4671 (1982)
Update date:2022-08-04
Topics: Ketones Enzymes Substrates Stereoselective Organic synthesis Heterocyclic Reductions Alcohol Dehydrogenase Tetrahydropyran-4-ones
Haslegrave, J. Anthony
Jones, J. Bryan
Horse liver alcohol dehydrogenase (HLADH) has been found to be an efficient catalyst for the reduction of O-heterocyclic ketones.Preparative-scale HLADH-catalyzed reductions of 2-substituted tetrahydropyran-4-ones are enantioselective, with reduction of e
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