SPECIFIC REMOVAL OF O-METHOXYBENZYL PROTECTION BY DDQ OXIDATION

Article abstract of DOI:10.1016/S0040-4039(00)86974-9

Methoxybenzyl protecting groups of alcohols were readily and efficiently removed with DDQ in CH2Cl2-H2O at room temperature.Under these neutral conditions, other usual protecting groups, isopropylidene, methoxymethyl, benzyloxymethyl, tetrahydropyranyl, acetyl, t-butyldimethylsilyl, benzyl, benzoyl, and tosyl, as well as functional groups, epoxide, double bond, and ketone, were remained unchanged.