Journal of Organic Chemistry p. 4471 - 4477 (1982)
Update date:2022-08-04
Topics:
Watkins, Bruce E.
Rapoport, Henry
Acylimidazoles have been alkylated with trialkyloxonium tetrafluoroborates to form acylimidazolium salts.These salts, particularly (benzyloxycarbonyl)imidazolium salts, are shown to be effective agents for the direct, mono-N-protection of deoxynucleosides as their acyl derivatives.These acyl nucleosides are also available via thiocarbamate intermediates.Thus 3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine (4b), on treatment with phenyl chlorothioformate, gave the 6-thiophenyl-substituted purine 38a.The thiophenyl group of 38a can be replaced by hydrogen, amino, and alkoxy groups to give a variety of substituted purine deoxyribonucleosides.
View MoreShandong Xinke Petrochemical Co., Ltd.
Contact:+86-546-7277016
Address:Gudao Industrial Park, Hekou District, Dongying, Shandong Province, China
website:http://www.oceanchem-group.com
Contact:86-536-8596048
Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
Hangzhou TJM Chemical Trade Co., Ltd
Contact:86-571-88223276 86-13388481653
Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
Nanjing Vincero International Trading Co.,Ltd
Contact:8618936897229
Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Contact:+86-0592 5353131
Address:No.56 Guani Road Software Park 2,Siming District
Doi:10.1021/om049217i
(2005)Doi:10.1021/om00073a013
(1983)Doi:10.1055/s-2004-834822
(2004)Doi:10.1016/j.bmcl.2004.10.013
(2005)Doi:10.1155/EDR.2001.217
(1937)Doi:10.1016/S0022-328X(00)92897-3
(1982)