Chemical and Pharmaceutical Bulletin p. 2255 - 2261 (1992)
Update date:2022-08-04
Topics:
Kitamura
Harano
Hisano
A simple method for synthesis of 2-aryl-substituted 3,3-dimethylindoline derivatives was established by the reaction of 1-acyl-2-hydroxy-3,3-dimethylindoline with electron-rich arenes in the presence of boron trifluoride-diethylether in dioxane. In the reaction with β-naphthol, a pair of isolable diastereomeric atropisomers was isolated. The conformations of both atropisomers were determined by single crystal X-ray analyses. The substitution reaction behavior toward various arenes was accounted for in terms of frontier molecular orbital (FMO) theory.
View Morewebsite:http://www.herbpurify.com
Contact:0086-028-85249238
Address:Room709-C1,Incubator Building, Tianfu Life Science Park No.88,Keyuan Road,Gaoxin district,Chengdu City,Sichuan Prov,China
Tianjin Te-An Chemtech Co., Ltd.(expird)
Contact:+86-22-65378638
Address:A5-8, No.80 Haiyun Street, TEDA
Contact:
Address:308# dongwu avenue dongxihu district wuhan city
QINGDAO DEVELOP chemistry Co.,Limited
Contact:+86-532-85807910
Address:98#Nanjing Road, Qingdao, China 266071
Xiamen Goodhealth Pharmchem Co., Ltd.
Contact:0086-592-2097683
Address:404R No.2 54# Minzu Rd., Xiamen, China
Doi:10.1016/S0040-4039(00)88648-7
(1982)Doi:10.1007/s11176-005-0158-5
(2004)Doi:10.1055/s-1982-29921
(1982)Doi:10.1134/S1070363207120201
(2007)Doi:10.1002/anie.201811946
(2018)Doi:10.1016/j.bmcl.2014.07.086
(2014)
