FACILE SYNTHESIS OF 4-SUBSTITUTED PYRIDINES USING GRIGNARD REAGENTS

Article abstract of DOI:10.1016/S0040-4039(00)87747-3

N-t-Butyldimethylsilylpyridinium triflate (2) reacted with Grignard reagents at 4-position with almost complete regioselectivity (<*>99percent) to afford the corresponding 1,4-dihydropyridine derivatives (3), which are easily oxidized by oxygen to give 4-substituted pyridines (4: 58-70percent).