Platinum(II) Complexes of Nitroimidazoles: Synthesis, Characterisation, and X-Ray Crystal Structures of cis-dichlorobisplatinum(II) and trans-dichlorobisplatinum(II)

DOI: 10.1039/DT9850000795

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Journal of the Chemical Society, Dalton Transactions p. 795 - 802 (1985)

Update date:2022-08-03

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Authors:

Bales, John R.

Mazid, Muhammed A.

Sadler, Peter J.

Aggarwal, Aneel

Kuroda, Reiko

et al. et al.

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Article abstract of DOI:10.1039/DT9850000795

A range of complexes of type 2X₂> (where L is a substituted 5-nitroimidazole, and X₂ is a dihalide or a dicarboxylate) has been prepared and characterised by a variety of methods, including 195Pt n.m.r. spectroscopy.These 5-nitroimidazole complexes had a cis stereochemistry as exemplified by the X-ray crystal-structure determination of cis-dichlorobis<1-(2'-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole>platinum(II) .In addition, a number of analogous complexes of 2- and 4-nitroimidazoles were prepared.The 2-nitroimidazoles appeared to form the thermodynamically favoured trans complexes, rather than the kinetically favoured cis products.This was verified for trans-dichlorobis<1-(2'-hydroxy-3'-methoxypropyl)-2-nitroimidazole>platinum(II) 1/a>.This complex showed an unusual loss of planarity between the nitro-group and the imidazole ring, giving a dihedral angle of 45.6 deg.The geometry of the 4-nitroimidazole complexes was not determined.Co-ordination of the nitroimidazole ligand to Pt^II lowered the wavelength of the ?-?^* electronic absorption band, and reduced the polarographic reduction potential by ca. 0.15-0.2V.

Full text of DOI:10.1039/DT9850000795

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