Platinum(II) Complexes of Nitroimidazoles: Synthesis, Characterisation, and X-Ray Crystal Structures of cis-dichlorobisplatinum(II) and trans-dichlorobisplatinum(II)

DOI: 10.1039/DT9850000795

Source and publish data:

Journal of the Chemical Society, Dalton Transactions p. 795 - 802 (1985)

Update date:2022-08-03

Topics:

Authors:

Bales, John R.

Mazid, Muhammed A.

Sadler, Peter J.

Aggarwal, Aneel

Kuroda, Reiko

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/DT9850000795

A range of complexes of type 2X₂> (where L is a substituted 5-nitroimidazole, and X₂ is a dihalide or a dicarboxylate) has been prepared and characterised by a variety of methods, including 195Pt n.m.r. spectroscopy.These 5-nitroimidazole complexes had a cis stereochemistry as exemplified by the X-ray crystal-structure determination of cis-dichlorobis<1-(2'-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole>platinum(II) .In addition, a number of analogous complexes of 2- and 4-nitroimidazoles were prepared.The 2-nitroimidazoles appeared to form the thermodynamically favoured trans complexes, rather than the kinetically favoured cis products.This was verified for trans-dichlorobis<1-(2'-hydroxy-3'-methoxypropyl)-2-nitroimidazole>platinum(II) 1/a>.This complex showed an unusual loss of planarity between the nitro-group and the imidazole ring, giving a dihedral angle of 45.6 deg.The geometry of the 4-nitroimidazole complexes was not determined.Co-ordination of the nitroimidazole ligand to Pt^II lowered the wavelength of the ?-?^* electronic absorption band, and reduced the polarographic reduction potential by ca. 0.15-0.2V.

Full text of DOI:10.1039/DT9850000795

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:(NO₂CCHNC(C₆H₄F)N(CH₂CH₂OH))2PtCl₂

Cas No:84431-21-0

R&D Labs maybe for 84431-21-0

Taizhou KEDE Chemical.Co.,Ltd.

Contact:86-576-84613060

Address:Jiangkou Chemical Zoon
Hangzhou Taiyan Trading Co., Ltd(expird)

Contact:+86-13777583958

Address:NO.63, Xingyi Street, Xihu District, Hangzhou, Zhejiang, China
BOC Sciences

website:https://www.bocsci.com/

Contact:1-631-485-4226

Address:Ramsey Road
GBXF SILICONES CO.,LTD

website:http://www.gbxfsilicones.com/

Contact:86-25-68900673

Address:He Country Provincial Fine Chemical Industrial Park of Chaohu city,Anhui province,China
A.M FOOD CHEMICAL CO., LIMITED

Contact:86-531-87100375

Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China

Relevant to this article

Cdc7 kinase inhibitors: Pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships

Doi:10.1021/jm700956r
(2008)
Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4-d]pyrimidin-4-ylamines

Doi:10.1016/j.tetlet.2007.04.035
(2007)
THE MECHANISM OF PHOTOLYSIS OF N-METHYLDIHYDROBERBERINE SALTS AND A SEQUENCE FOR TRANSPOSITION OF RING D SUBSTITUENTS

Doi:10.1016/S0040-4039(00)87687-X
(1982)
Non-peptidic inhibitors of human neutrophil elastase: The design and synthesis of sulfonanilide-containing inhibitors

Doi:10.1016/S0968-0896(96)00216-7
(1996)
Doi:10.1039/jr9520002525
(1952)
Comparative studies on the amidoalkylating properties of N-(1-methoxyalkyl)amides and 1-(N-acylamino)alkyltriphenylphosphonium salts in the michaelis-arbuzov-like reaction: A new one-pot transformation of N-(1-methoxyalkyl)amides into phosphonic or phosphinic analogs of N-Acyl-α-amino acids

Doi:10.1080/10426507.2012.729237
(2013)

Article Doi