Journal of Organic Chemistry p. 715 - 721 (1983)
Update date:2022-09-26
Topics:
Goering, Harlan L.
Kantner, Steven S.
Tseng, Chung Chyi
Alkylation of allylic N-phenylcarbamates by deprotonation, complexation with CuI in THF, and addition of 1 equiv of RLi results in syn γ-alkylation in both cyclic and acyclic systems.This procedure gives higher stereo- and regiospecificity than when allylic N-phenylcarbamates are reacted with 3 equiv of etheral LiCuR2.A mechanism is presented which incorporates an intramolecular oxidative addition leading to a ?-allyl complex (3) which undergoes reductive elimination to give the syn γ-alkylation product.
View MoreZhejiang Haizhou Pharmaceutical Co., Ltd.
website:https://www.haizhoupharma.com/
Contact:+86-576-88221016
Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Wuhan Chemchemical Co., Ltd.(expird)
Contact:15973022782
Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Anhui New Star Pharmaceutical Development Co., Ltd
Contact:013956922763
Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Qingdao Kylin Trading Co., Ltd.
Contact:0086-532-68979884/58972912/68972263/65/88171519
Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Arshine Pharmaceutical Co., Limited
website:http://www.cnarshine.com
Contact:0731-88503671
Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
Doi:10.1021/jm00388a007
(1987)Doi:10.1016/j.farmac.2004.10.002
(2005)Doi:10.1021/ic048578n
(2005)Doi:10.1107/S0108270104024424
(2004)Doi:10.1002/chem.200400923
(2005)Doi:10.1016/j.tet.2006.07.099
(2006)
