Bioorganic and Medicinal Chemistry Letters p. 589 - 593 (2005)
Update date:2022-08-03
Topics:
Palin, Ronald
Barn, David R.
Clark, John K.
Cottney, Jean E.
Cowley, Phillip M.
Crockatt, Marc
Evans, Louise
Feilden, Helen
Goodwin, Richard R.
Griekspoor, Frank
Grove, Simon J.A.
Houghton, Andrea K.
Jones, Philip S.
Morphy, Richard J.
Smith, Alasdair R.C.
Sundaram, Hardy
Vrolijk, David
Weston, Mark A.
Wishart, Grant
Wren, Paul
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
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