A new synthesis of alkyl-1-alkyl-2-methylpyrrole-3-carboxylates by ring transformation of 2-chloro-2-acetimidoylbutyrolactones

Article abstract of DOI:10.1016/S0040-4020(99)00108-8

Reaction of 2-chloro-2-acetimidoylbutyrolactones with sodium methoxide or sodium ethoxide in the corresponding alcohol provides a facile one-step synthesis of methyl or ethyl 1-alkyl-2-methylpyrrole-3-carboxylates from readily available starting materials.