Development of specific inhibitors for heparin-binding proteins based on the cobra cardiotoxin structure: An effective synthetic strategy for rationally modified heparin-like disaccharides and a trisaccharide

Article abstract of DOI:10.1016/j.carres.2004.11.029

Recently, a new heparin disaccharide-binding site on the convex side of cobra cardiotoxin (CTX) was identified by NMR spectroscopy and molecular modeling. To further characterize this site two heparin-like disaccharides were synthesized for binding studie