4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β- hydroxysteroid dehydrogenase II. Part 1: Synthetic approach

Article abstract of DOI:10.1016/j.tetlet.2005.01.003

17β-Hydroxysteroid dehydrogenase II (17β-HSD II) antagonists may provide an important way into preventing the onset of osteoporosis. The discovery of 4,5-disubstituted cis-pyrrolidinones as 17β-HSD II inhibitors led to the development of an efficient intr