Synthesis and applications of a fluorous THP protective group

Article abstract of DOI:10.1016/S0040-4039(99)00866-7

A recyclable fluorous labeled THP protecting group has been developed that allows for simple purification of small molecules by liquid-liquid extraction with FC-72/MeCN, and of larger or more polar molecules by solid phase extraction with fluorous reverse phase silica gel. In addition, we report a new glycosylation method which uses the Cp₂ZrCl₂-AgClO₄ reagent system to activate an anomeric sulfoxide.