Preparation of iodine-123 labeled AM251: A potential spect radioligand for the brain cannabinoid CB1 receptor

DOI: 10.1002/(SICI)1099-1344(199610)38:10<875::AID-JLCR908>3.0.CO;2-G

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 875 - 881 (1996)

Update date:2022-08-03

Topics:

Authors:

Lan, Ruoxi

Gatley, S. John

Makriyannis, Alexandros

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Article abstract of DOI:10.1002/(SICI)1099-1344(199610)38:10<875::AID-JLCR908>3.0.CO;2-G

We report the synthesis and labeling with iodine-123 of N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole -3-carboxamide (AM251). This compound is an anlog of the recently described cannabinoid receptor antagonist, R141716A,

Full text of DOI:10.1002/(SICI)1099-1344(199610)38:10<875::AID-JLCR908>3.0.CO;2-G

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