Synthesis of monomers bearing at the 2′-position cyanomethoxycarbonyl group for phosphoramidite oligonucleotide synthesis

Article abstract of DOI:10.1081/NCN-200026053

A novel series of phosphoroamidites for the synthesis of 2′-modified oligonucleotides was designed and synthesized on the base of 2′-amino uridine and 2′-amino arabinoadenosine. The amino groups in these compounds were acidified by bis-cyanomethyl esters