Macrolide Total Synthesis. The Synthesis of Seco-Acid Derivatives for the synthesis of Methymycin and 10-Deoxymethymycin

DOI: 10.1021/jo00156a032

Source and publish data:

Journal of Organic Chemistry p. 1312 - 1325 (1983)

Update date:2022-08-04

Topics:

Authors:

Ireland, Robert E.

Daub, John P.

Mandel, Gretchen S.

Mandel, Neil. S.

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Article abstract of DOI:10.1021/jo00156a032

A stereoselective synthesis of the chiral seco-acid derivatives for the synthesis of methymycin and 10-deoxymethymycin from carbohydrate precursors is described.Additionally, a formal total synthesis of methymycin is achieved.The synthetic scheme proceeds

Full text of DOI:10.1021/jo00156a032

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