Macrolide Total Synthesis. The Synthesis of Seco-Acid Derivatives for the synthesis of Methymycin and 10-Deoxymethymycin

Article abstract of DOI:10.1021/jo00156a032

A stereoselective synthesis of the chiral seco-acid derivatives for the synthesis of methymycin and 10-deoxymethymycin from carbohydrate precursors is described.Additionally, a formal total synthesis of methymycin is achieved.The synthetic scheme proceeds